Zamkatimu pankhaniyi:
1. Kukula kwa Amino Ads
2. Zojambula
3. Kupanga kwamankhwala
4.clation
5. Psinthesis
6. Makina a Syscochemical
7. Kuzindikira
8.. Antimicrobial
9. Mitundu yachangu
10. Mapulogalamu muzodzikongoletsera
11. Mapulogalamu muzodzikongoletsera tsiku ndi tsiku
Amino acid surfactonts (AAS)ndi gulu lazinthu zopangidwa ndi kuphatikiza magulu a hydrophobic ndi acid imodzi kapena zingapo. Pankhaniyi, amino acid amatha kukhala opangidwa kapena opangidwa kuchokera ku mapuloteni a protein kapena magwero ofanana. Pepala ili limafotokoza mwatsatanetsatane njira zopangira za Aas ndi zotsatira za njira zosiyanasiyana zothandizira zinthu zomaliza, kuphatikizapo kusungunuka, kuphatikizapo kukhazikika, zosokoneza komanso zowopsa. Monga gulu la okonda kuchuluka, mankhwala a AAS chifukwa cha mawonekedwe awo osiyanasiyana amapereka mwayi waukulu wamalonda.
Popeza kuti owonjezerawa amagwiritsidwa ntchito kwambiri m'malo ophatikizika, ma emulsifiers, zotupa zotupa, zotupa zochira mafuta ndi mankhwala opanga mankhwala, ofufuza sanasiye kutcheratu zochulukirapo.
Ogwiritsa ntchito ndi zinthu zoyimilira kwambiri zomwe zimadyedwa mochuluka tsiku lililonse padziko lapansi ndipo zadzetsa mavuto padzikoli.Kafukufuku wasonyeza kuti kugwiritsa ntchito zachikhalidwe zochulukirapo kumatha kukhala ndi vuto loipa.
Masiku ano, osadandaula, Bioodegradiity ndi bioocomative ndiofunikira kwambiri kwa ogula ngati zofunikira ndi magwiridwe antchito okonda.
Biosorictants ndi malo okhala okonda zachilengedwe omwe amapangidwa mwachilengedwe ndi tizilombo tating'ono monga mabakiteriya, bowa, kapena yisiti, kapena wobisika.Chifukwa chake, Bioristactallant amathanso kukonzedwa ndi mabotolo opangidwa ndi ma coucular zachilengedwe kuti mugwirizane ndi mitundu yachilengedwe yomwe imakhala yachilengedwe yopezeka, monga phospholiphols, alkyl glycosides ndi acyl amino acid.
Amino acid surfactonts (AAS)ndi amodzi mwazomwezi zimapangidwa, nthawi zambiri zimapangidwa kuchokera ku nyama kapena zida zaulimi. Zaka makumi awiri zapitazi, Aa akopa chidwi chachikulu kuchokera kwa asayansi monga momwe akutchulidwira, osati chifukwa choti atha kuphatikizika ndi zinthu zosavulaza, ndipo zimapangitsa kuti akhale otetezeka chifukwa cha chilengedwe.
AA limatha kufotokozedwa ngati gulu la okonda ma amino acid okhala ndi ma amino acid (Ho 2 cl-h 2) Madera awiri ogwira ntchito a Amacid acid amalola kuti asungunuke ambiri okonda mafuta osiyanasiyana. Makina okwanira 20 a ma amino amadziwika amadziwika kuti alipo mwachilengedwe ndipo ali ndi udindo pazomwe zimachitika muzomera zosiyanasiyana komanso zochitika m'moyo. Amasiyana wina ndi mzake molingana ndi otsalira r (Chithunzi 1, PK A ndiye Logorithm wa acid Tsulutions). Ena ndi polar ndi hydrophobic, ena ndi polar ndi hydrophilic, ena ndi oyambira ndipo ena ali acidic.
Chifukwa ma amino acid ndi osinthika osinthika, ogwiritsa ntchito adasintha kuchokera ku amino acid amakhalanso ndi mwayi wokhala ndi chilengedwe. Kupanga kosavuta komanso kwachilengedwe, zoopsa zotsika komanso zodzisintha mwachangu zimawapangitsa kukhala apamwamba kuposa oyendetsa masewera olimbitsa thupi. Kugwiritsa ntchito zida zosinthidwa (mwachitsanzo, ma amino acid ndi mafuta a masamba), aas imatha kupangidwa ndi njira zodziwika bwino zachuma ndi njira zamagetsi.
Kumayambiriro kwa zaka za m'ma 1900, amino acid adapezeka koyamba kugwiritsidwa ntchito ngati magawo a kaphatikizidwe ka orfackanti.AA ankagwiritsidwa ntchito makamaka ngati zosungira zachilengedwe komanso zodzikongoletsera.Kuphatikiza apo, AA anapezeka kuti anali otanganidwa kwambiri ndi mabakiteriya osiyanasiyana, zotupa, ndi ma virus. Mu 1988, kupezeka kwa aasi otsika mtengo kwambiri pa ntchito. Masiku ano, ndi chitukuko cha biotechnology, ma amino acid amathanso kuphatikizidwanso pamalonda pamlingo waukulu kwambiri, chomwe chimatsimikizira kuti aAs kupanga chilengedwe ndi kukhala ochezeka.
01 chitukuko cha amino acids
Poyambirira zaka za zana la 19, pomwe amapezeka mwachilengedwe adapezeka koyamba, zomanga zawo zidanenedweratu kuti ndizofunika kwambiri - zotheka ngati zida zophika pokonzekera nthumwi zophikira. Kafukufuku woyamba pa kaphatikizidwe wa Aasi adanenedwa ndi Bongo mu 1909.
Mu kafukufuku ameneyo, N-Acylglycine ndi N-Acylalanine adayambitsidwa ngati ma hydrophilic magulu okonda kuchuluka. Ntchito yotsatira idakhudza kaphatikizo wa lipoamini acids (AAAS) pogwiritsa ntchito glycine ndi Alanine, ndi Hentrich et al. adasindikiza zingapo zomwe zapezedwa,Kuphatikiza ntchito yoyamba ya patenti, pakugwiritsa ntchito ma acyl sarcossitete ndi mchere wa acyl monga orfactontPambuyo pake, ofufuza ambiri anafufuza kapangidwe kake ndi ma descoochemical ku Acyl Amanid. Mpaka pano, mabuku ambiri amasindikizidwa pa synthesis, katundu, kugwiritsa ntchito mafakitale ndi biodegradiodi yosungira AAA.
02 zojambula
Mafuta omwe sakhala polar hydrophobic mafuta maunyolo a AAS akhoza kusiyanasiyana, kutalika kwa unyolo ndi nambala.Kusintha kwa zinthu ndi ntchito zapamwamba kwambiri za AA kumafotokozera mitundu yawo yosiyanasiyana yosiyanasiyana ndi ma descoofmical komanso zachilengedwe. Magulu a aapo a AAa amapangidwa ndi amino acid kapena ma peptides. Kusiyana kwamutu kumangoganiza za Adsorption, kugawana ndi kwachilengedwe kwa okonda izi. Magulu ogwirira ntchito m'gululi ndiye kuti azindikire mtundu wa aas, kuphatikiza mawu achinsinsi, anionic, osagwirizana, komanso amphoniric. Kuphatikiza kwa hydrophilic amno acids ndi hydrophobic kutalika kwa zinthu zazitali kumapanga mawonekedwe ampingo omwe amapangitsa molekyulu bwino kwambiri. Kuphatikiza apo, kukhalapo kwa asymmetric kaboni kaboni molekyu kumathandiza kuti chiba ndi mamolekyulu.
03 Mankhwala Opangidwa
Ma Peptides onse ndi ma polypeptives ndi zinthu zowonjezera polymerization za izi 20 α-pro pro pro pro pro pro proteinic zints. Onse a Amini acid ali ndi ma acid acid acids (-cooh) ndi gulu la amino ntchito (-Nh 2), onse ophatikizidwa ndi tetrahelt y atomu yomweyo. Amino acid amasiyana wina ndi mnzake ndi magulu osiyanasiyana omwe amaphatikizidwa ndi α-carbon (kupatula lycne, komwe magulu ndi hydrogen). Kusiyana uku kumatsimikiziranso kusungunuka kwa amino acid amadzi.
Amino Ads ndi tral (kupatula glycine) ndipo amagwira ntchito mwachilengedwe chifukwa ali ndi mitundu inayi yolumikizidwa ndi kaboni ya alpha. Ma amino acid ali ndi magwiridwe awiri otheka; Ndiwo zithunzi zopanda pake za wina ndi mnzake, ngakhale kuti chiwerengero cha a L-Stuoomers ndi chachikulu kwambiri. Gulu la R-lomwe lilipo m'matino acid (phenylalanine, tyrosine, typrophan) ndi aryl, zomwe zimayambitsa kuyamwa kwambiri kwa UV pa 280 nm. Acidic α-cooh ndi yoyambira α-nh 2 mu amino acid amatha kugwiritsa ntchito, ndipo onse awiri, akupanga njira yofanana, yopanga kufanana kwa mathion omwe ali pansipa.
R-cooh ↔r-coo-+ H+
R-nh3+↔r-nh2+ H+
Monga tikuwonera mu kusiyanasiyana kwa mandiilibrium pamwambapa, amino acid ali ndi magulu awiri acidic; Komabe, gulu la carboxyl ndilochulukirapo acidic poyerekeza ndi gulu la Amino. PH 7.4, gulu la carboxyl likugwedezeka pomwe gulu la Amino limafotokozedwa. Mamino acids ndi magulu osasanja a saino amalowerera bwino pa Ph ndi mawonekedwe a Zwiterteter.
04 Gulu
AA limatha kutchulidwa malinga ndi njira zinayi, zomwe zimafotokozedwa pansipa.
4.1 Malinga ndi chiyambi
| Malinga ndi chiyambi, Aas amatha kugawidwa m'magulu awiri motsatira. Khalidwe lachilengedwe Zachilengedwe mwachilengedwe zomwe zimakhala ndi ma amino acid alinso ndi kuthekera kochepetsa nkhawa, ndipo ena amapitilira tanthauzo la glycolipids. AA amadziwikanso ngati Lipopfets. Lipopptides ndi mankhwala ocheperako ochepetsa, nthawi zambiri amapangidwa ndi mtundu wa bacilas.
Aas oterewa agawika m'magawo atatu:Surrantn, iurin ndi fengycin.
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| Banja la Peptides yogwira ntchito imagwira ntchito ndulu zamitundu yosiyanasiyana ya zinthu zosiyanasiyana,Monga taonera Chithunzi 2A, momwe c12-C16-C16 yosavomerezeka β-hydroxy mafuta tinty a asidi amalumikizidwa ndi peputiyi. Peptide yogwira ntchito ndi lacrocyclic pomwe mphete imatsekedwa ndi catalysis pakati pa C-Sermisus ya mafuta a β-hydroxy ndi peptide. Mu subclass wa iTurin, pali mitundu isanu ndi umodzi yayikulu, iUurin A ndi C, Mycosubtulinin ndi bacillomycin d, f ndi l.Nthawi zonse, ofunsawo amalumikizidwa ndi a C14-C17 ofana a β-amino mafuta acids (maunyolo amatha kukhala osiyana). Pankhani ya ekurycin, gulu la amino ku β-udindo limatha kupanga mgwirizano ndi C-termisus motero ndikupanga mawonekedwe a lacrocyctic lactackic.
Subclass Fengycin ili ndi Fengycin A ndi B, omwe amatchedwanso Plipastatin pomwe Tyr9 amakokedwa.The Dectopeptide imalumikizidwa ndi C14 -C18 Yotalika kapena yosasinthika β-hydroxy mafuta unyolo. Pulogalamu yopanga, plipastatin ndi macrocyctic.
Gulu lopanga AA limathanso kuphatikizidwa pogwiritsa ntchito mtundu uliwonse wa acidic, woyambira komanso wosalowerera acid. Asino acid wamba amagwiritsidwa ntchito pa kaphatikizidwe wa AAS ndi glutamic acid, serine, asparnic, asparnic, Alanirine, Alanirine, a Alanins. Zowonjezera izi zowonjezera zimatha kukonzedwa ndi mankhwala, enzymatic, ndi njira zam chemozzy; Komabe, pakupanga aas aas, masiko a mankhwala ali otheka kwambiri pachuma. Zitsanzo zodziwika bwino zimaphatikizapo n-Lauroyll-l-glutamic acid ndi n-malmitoyl-l-glutamic acid.
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4.2 Kutengera mitu ya Aliphatic miniti
Kutengera ndi unyolo wokhazikika, amino acid-zokhazikitsidwa okonda zimagawika m'mitundu iwiri.
Malinga ndi malo am'munsi
| AAS Mu mankhwala opatsirana a N-Otetezedwa, gulu la amino limasinthidwa ndi gulu la lipophilic kapena gulu la capoboxyl, zomwe zidapangitsa kuti zikhale zoyambira. Chitsanzo chosavuta cha N-Ofesi ya AAS ndi n-acyl amacina acid, omwe ndi Anionic ogwiritsa ntchito. AAS NAS ili ndi mgwirizano wapakati pa hydrophobic ndi ma hydrophilic magawo. Chingwe chomangirachi chimatha kupanga home ya haidrojeni, yomwe imathandizira kuwonongeka kwa zowonjezera izi m'malo a acidic, ndikupanga biodegragrable.
②c-opatsirana aas Mu mankhwala opatsirana a C-opatsirana, cholowa chimachitika pa gulu la carboxyl (kudzera mwa Amide kapena ESTER). Zophatikizidwa c-opatsirana (mwachitsanzo etters kapena Amides) ndizotengera zotengera zophatikizika.
③n- ndi c-opatsirana aas Mu mtundu uwu wa zochulukitsa, onse a amino ndi carboxyl ndi gawo la hydrophilic. Mtundu uwu ndi wochepera kwambiri wa amphongotic. |
4.3 Malinga ndi kuchuluka kwa michira ya Hydrophobic
Kutengera kuchuluka kwa magulu amutu ndi michira ya hydrophobic, aas amatha kugawidwa m'magulu anayi. Alemekezeka aasi, gemini (smier) mtundu aas, glycerolifid mtundu Aas, ndi bicefelic Trifililic (Bola) Mtundu wa AAS. Mafuta owongoka ndi okonda kuchuluka chopangidwa ndi amino acid ndi mchira umodzi wokha wa hydrophobic (Chithunzi 3). Gemini mtundu Aas ali ndi ma ammita awiri a acid a acid ndi michira iwiri ya hydrophobic pa molekyulu (Chithunzi 4). Mu mtundu uwu, AAasi awiri owongoka amalumikizidwa pamodzi ndi mlengalenga ndipo amatchedwanso kuti ali ndi mawonekedwe. Mu mtundu wa glyceroliptid aas, mbali inayo, michira iwiri ya hydrophobic imalumikizidwa ku gulu lomwelo la amino acid. Izi zimatha kuonedwa ngati ma analog a Monoglycerides, pophunzitsa phosfides, ali ku Bola-Mtundu wa AAS, amalumikizidwa mchira wa hydrophobic.
4.4 Malinga ndi mtundu wa gulu lamutu
①catic aas
Gulu la mutu wa mtundu uwu lazachuma lili ndi mlandu wabwino. Choyambirira choyambirira kwambiri aaka ndi ethyl cocoyl chimanga, chomwe ndi cha parrolidrone carboxytete. Njira zapadera komanso zosiyanasiyana zowonjezera izi zimapangitsa kuti ikhale yothandiza ophera tizilombo toyambitsa matenda, antimiticrobial othandizira, othandizira antitastic, zowongolera tsitsi, komanso kukhala odekha pamaso ndi khungu. Siparer ndi Muttre syntutheretide arlic-roclic aas ndikuwona zinthu zawo zamatumbo. Mu kafukufukuyu, adayankha zokolola zambiri zomwe zidapezeka pogwiritsa ntchito matenda a Schotten-Baumann. Ndikuwonjezera kutalika kwa ma alkyl ndi hydrophobity, zochitika zapadziko lapansi zimapezeka kuti zikuwonjezeka ndikuwonjezera michelle (cmc) kuti muchepetse. Chinanso ndi mapuloteni a quanterry, omwe amagwiritsidwa ntchito ngati chowongolera pamalonda osamalira tsitsi.
②anio aas
Mu anionic surfacylants, gulu la polar mutu wa outrical lili ndi mlandu woyipa. Sarcosine (Ch 3 -Nh-ch -cooh, n-cethylglycine), a amino, amagwirizana ndi nyenyezi zam'madzi, acine, -Cooh,) ndi yokhudzana ndi glycine, yemwe ndi amino acid wopezeka m'maselo a Mammalian. Lauric acid, tetradecanoic acid, oleriic acid ndi ma halides awo ndi ebster nthawi zambiri nthawi zambiri amagwiritsidwa ntchito posankhana ndi kusana kwa kusanza. Madzi ofatsa ndi ofatsa komanso chifukwa chake amagwiritsidwa ntchito pakamwa, shampoos, kuthira ziwanda, ma sunsch, zoyeretsa khungu, ndi zinthu zina zodzikongoletsera.
Anic anic anioft omwe ali ndi malonda omwe amapezeka amaphatikizira a sasoft CS-22 ndi Amiliteck-12, omwe ndi mayina a malonda a sodium n-cocoyl-l-glutate ndi glycrete, motsatana. Amilite nthawi zambiri amagwiritsidwa ntchito ngati wothandizira wowononga, wotsekerera, emulsifier komanso wobala, ndipo ali ndi ma sopo, kuyeretsa matupi, kuyeretsa misozi, maofesi anyumba. Amoni amagwiritsidwa ntchito ngati khungu lofatsa ndi kuyeretsa tsitsi, makamaka pakuyeretsa kwa nkhope, block storcnts, zopangidwa ndi ma shampoos, shampoos ndi zinthu zina zosamalira khungu.
③Zwitterionic kapena ampherotic aas
Amhorotic surfactonts zimakhala ndi masamba onse acidic komanso oyambira ndipo motero amasintha mlanduwo posintha mtengo wa pH. Mu media ya alkaline amakhala ngati Anionic surfactonts, pomwe m'magawo okhala ndi acidic amakhala ngati othandizira okonda komanso osalongosoledwa ngati a salomir ngati andapotala ngati anda. Lauryl lysine (ll) ndi alkoxy (2-hydroxypypyl) a arginine ndi okhawo odziwika odziwika omwe amakhazikitsidwa ndi Amino acid. LL ndi chinthu chophatikizira cha lysine ndi lauric acid. Chifukwa cha kapangidwe kake kamvula, ll ndi influble pafupifupi mitundu yonse ya ma sol sol, kupatula a alkaline kapena acidic sol sol sol sol. Monga ufa wa organic, LL ali ndi zomatira bwino kwa hydrophilic pamalowo komanso zolimba za mkangano, kupereka mphamvu zabwino kwambiri. Ll imagwiritsidwa ntchito kwambiri pakhungu ndi zowongolera tsitsi, ndipo zimagwiritsidwanso ntchito ngati mafuta.
④nonionic aas
Ogwiritsa ntchito osagwirizana amadziwika ndi magulu a m'mutu osalipira. EthOxy-New Ethoxtric Ortionicnts adakonzedwa ndi al-Sabagh et al. kuchokera ku sodi ya mafuta a mafuta. Munjira iyi, l-phenylalanine (lep) ndi L-Leucine adayamba kufulutsidwa ndi hexadecanol, kutsatiridwa ndikumata acid kuti apatse Amisiri Acids ADS. Amadzi ndi ester kenako amasinthana ndi ma ethylene oxide kuti akonzekere zotumphukira zitatu za phenylalanine ndi zigawo zingapo za polyoxyathylene (400 ndi 100). AA a Nonionic awa adapezeka kuti ali ndi zotumphukira bwino komanso zopukutira.
05 synthesis
5.1 Zolemba Zoyambira
Mu AA, magulu a hydrophobic amatha kuphatikizidwa ndi masamba a Amine kapena Carboxylic acid, kapena kudzera mwa utsogoleri wa acid a amino acid. Kutengera ndi izi, njira zinayi zopangira zilipo, monga zikuwonekera pa Chithunzi 5.
Njira za mkuyu.5 za ma amino acid
| Pa njira 1. Aminifilic Esster Enes amapangidwa ndi zotsatira zakhumi, nthawi zambiri kapangidwe kazinthu kumachitika pokana mowa wamafuta ndi ma amino acid pamaso pa othandizila kwa acidic ndi acidic. M'malo ena, sulufuric acid amachita chothandizira komanso chofufumitsa.
Payway 2. Amino acid acid amakhala ndi alkylamin kuti apange zomangirazo, zomwe zimapangitsa kuti ma synthesis a amidohilic amidoilic ammoric.
Panjira 3. Amido acids amapangidwa chifukwa cholemba magulu a Amine acid ndi Amido Acids.
Panjira 4. Alkyl alkyl acids adapangidwa ndi zomwe amagwiritsa ntchito magulu a Amine okhala ndi halolyal. |
5.2 Kupita patsogolo mu kaphatikizidwe ndi kupanga
5.2.1 kaphatikizidwe ka amino inchin acid / peptide orfactonts
N-Acyl kapena O-Acyl Amacid acid kapena ma peptides amatha kuphatikizidwa ndi enzyme-arymed acylation a amine kapena ma hydroxyl ndi mafuta acids. Lipoti loyambirira kwambiri pa lipose-free lipose - kaphatikizidwe ka Amino Amide kapena methyl esster derivibs ogwiritsa ntchito canida antaida antaida antatad Methyl ethyl ketone yakhala ikugwiritsidwanso ntchito ngati zosungunulira zina. Vonderhagen et al. adafotokozanso lipose ndi mapuloteni omwe ali ndi mapuloteni ndi ma amino acid, ma hydrolysysys and / kapena osiyidwa (mwachitsanzo, Dimethylfermormide / madzi a Methyl attane.
M'masiku oyambilira, vuto lalikulu ndi enzyme - zokopa za Aasi zinali zokolola zochepa. Malinga ndi vametty et al. Zokolola za n-tetradecanoy mankhwala a aciyel anali ndi 2% yokha -10% ngakhale atagwiritsa ntchito litose osiyanasiyana ndikusintha 70 ° C Pulings masiku ambiri. Montet et al. Anakumananso ndi mavuto obwera chifukwa cha zokolola za amino acid mu synthesis a n-acyl lysine amagwiritsa ntchito mafuta acid ndi mafuta. Malinga ndi iwo, zokolola zambiri pazogulitsa zinali 19% pansi pa zosungunulira komanso kugwiritsa ntchito ma sol sol sol. Vuto lomwelo lidakumana ndi valvetty et al. Mu kaphatikizidwe wa N-CBZ-L-lysine kapena n-cbz-lysine meth esters.
Mu kafukufukuyu, adanenanso kuti zokolola za 3-o Nagao ndi Kito adaphunzira za acylation ya L-Serneder, L-Homesine, l-t-t-t-t-troserine L-verenine ndikusiyidwa.
Ofufuza ambiri athandizira kugwiritsa ntchito njira zotsika mtengo komanso zosavuta kupezeka pa kaphatikizidwe wa aasi. Soo et al. Anatinso kukonzekera mafuta a kanjedza kumagwira ntchito bwino kwambiri ndi liponzyme. Adanenanso kuti zokolola za zinthuzo zingakhale bwino ngakhale nthawi yayitali ndikuwononga masiku (masiku 6). Gerngova et al. Anafufuza kapangidwe kake ndi zochitika zapamwamba za choral n-palmiyoyl aas pokhazikika pa methionine, proline, leucine, phenyllalanine ndi phenylglycine mu zosakaniza za cyclic /. Pang ndi Chu adafotokoza kapangidwe ka Amino Acid monomers ndi dikarboxylic acid proctomers acid acid
Cantaeuzezene ndi Guerreiro adanenanso za mabungwe a acid acid a Boc-Ala-Amo ndi Baru-Asher-asm-asm-asm-asm-asm-asm-asm-asm-asm-asm-asm-asm-asm-assoromene osungunuka komanso agarose 4b (Sepharose 4b). Mu kafukufukuyu, zomwe Boc-Ala-Ala-oh ndi mafuta owotcha mpaka ma carbons okwanira 16 (51%), ma carbons okwana 63% [63% [63). 99.9%) Mu zokolola kuyambira 58% mpaka 76%, yomwe idapangidwa ndi mapangidwe a Amidere-arp-arg-ome, komwe ndalama zaponda zimachitidwa ngati chothandizira.
5.2.2 Kaphatikizo wa Amino-Cinod acid / peptide orfactonts
Amino acid-pormi acid orfactonts zimakhala ndi mamolekyulu awiri olunjika ndi mutu. Pali njira ziwiri zotheka za chemonzymatic synthesis a gemini-mtundu amino acid-zochokera pazaka 4 ndi 7). Mu Chithunzi 6, 2 amino acid zotumphukira zimachitika ndi gulu lokhalamo ngati gulu la space kenako magulu awiri a hydrophobic amayambitsidwa. Mu chiwerengero 7, madera awiri owongoka amalumikizidwa pamodzi ndi gulu la a bruncticle.
Kukula koyambirira kwa enzyme - chopondera kaphatikizidwe cha gemini Lipofoamino acid acid adachita upainiya ndi lunguVE et al. Yoshimura et al. adafufuza kaphatikizidwe, Adsorption ndi kuphatikiza kwa amino acid-pormini ortictor potengera cystine ndi n-alkyl bromide. Ogwiritsa ntchito ophatikizika adafanizidwa ndi zogwirizana zofananira zofananira. Faustino et al. Tafotokozerani kapangidwe ka aniomeric anio-zochokera ku L-cystine, D-cystine, ma cystine, olimine, Stadteium-State Fluorescence madandaulo a iwo. Zinawonetsedwa kuti mtengo wa cmc wa gemini anali wotsika poyerekeza monomer ndi gemini.
Kuphatikizika kwa ma gemini a gemini aas ogwiritsa ntchito aa ndi spacer, pambuyo pake, kutsatiridwa ndi kulowetsa gulu la hydrophobic
Nice.7 synthesis a gemini a and
5.2.3 Kaphatikizidwe wa Glycerolifid amino acid / peptide orfactonts
Glycerolipid amino acid / peptide orfactonts ndi gulu latsopano la lipid amino acid omwe ali ndi maumboni a ma acid a glycerol acid olumikizidwa ndi elster. Kaphatikizidwe ka awa aorsendus amayamba ndikukonzekera ma glycerol ess of Amani acid otentha komanso pamaso pa chothandizira cha acidic (mwachitsanzo bf 3). Enzyme-yothandizira synthesis (pogwiritsa ntchito ma hydrolases, mapuloteni ndi litulo ngati othandizira) ndi njira yabwino (Chithunzi 8).
Syzyme-yothandizira kapangidwe ka artine ya arlinine glycerides arjoung pogwiritsa ntchito papain yanenedwa. Kaphatikizidwe wa ESTER EST CORJAGEs kuchokera kwa Acetylarginine ndikuwunika zinthu zawo za Syycochemin anenedwanso.
Nice.8 synthesis a Mono ndi diacylglyceroll amino acid conjukupeza
Spacer: NH- (Ch2)10-Nh: Phatikizani
Spacer: NH-C6H4-Nh: Katundu2
Spacer: Ch2-Kala2: Kuphatikiza3
Kuphatikizika kwa mkuyu.9 kanjira kwa symmetric ovekera komwe amachokera ku Tris (hydroxymethyl) aminomethane
5.2.4 Synthesis ya Bola-Sounce Acid / PUPTIMO ORTACTUTTESTS
Amino Acids opezeka acid ali ndi ma amino acid omwe amalumikizidwa ndi unyolo yemweyo. Franceschi et al. Tafotokozerani kapangidwe ka bola-mtundu wa ma amino acid (d- kapena l-anine kapena l-historine) ndi 1 ma alkyl a kutalika kosiyanasiyana. Amakambirana za kapangidwe kake ndi kuphatikiza kwa kuchuluka kwa zilembo za amino ndi kachilombo ka Amini Acid (pogwiritsa ntchito sayansi yachilendo β-amino acid kapena mowa wa C12 -C20 Spacer. Acids osadziwika omwe amagwiritsidwa ntchito amatha kukhala aminokisani a aminothy (azt) - azt) - Amino)-aminornene amino acid, ndipo mankhwala a amino adachokera ku Azt (Chithunzi 9). Kaphatikizidwe ka matenda amtundu wa Bermetrical wopezeka kuchokera ku Tris (hydroxymethyl) aminometane (Tris) (Chithunzi 9).
06 Zojambula Zakusintha
Ndizodziwika bwino kuti amino acid modclefactont (AAAS) ndi osiyana ndi chilengedwe)
Kutengera katundu wopata ma amino acid (mwachitsanzo, mawonekedwe a ma cmc, njira kutentha kwa Kraft), zotsatirazi zimafikiridwa pambuyo pa maphunziro a aasi
6.1 michere yovuta (CMC)
Michelle yovuta kwambiri ndi imodzi mwa magawo ofunikira aorrectolts ndi ma lymobilizar mchira wa hydrocabicity, motero amachititsa kuti zinthu ziziyenda bwino. Zotengera kutengera ma amino acid nthawi zambiri zimakhala ndi zochepetsetsa za CMC poyerekeza ndi zopatsa zomwe zili wamba.
Kuphatikiza mosiyanasiyana kwa magulu amutu ndi michira ya hydrophobic (mono-curic amder, Amisiki a AI-CARIDIC AMIDE, A B-Cirtic Amider), infornante et al. Anasisita aas atatu a Arline-a Aas ndi kuwerengera cmc ndi γcmc (mawonekedwe a vMC), kuwonetsa kuti cmc ndi γcmc mikhalidwe yotsika ndi mchira wa hydrophobic. Pakuphunzira kwina, pailesi ndi mmera wa cmc wa n-α-acylarigine zopha ma atomu a hydrophobic carbon (tebulo 1).
Yoshimura et al. Anafufuza cmc ya Cysteine-Cemini Acid-Sourti Acid Acidststs ndipo adawonetsa kutalika kwa ma cmc, omwe adatsimikiza kuti kutalika kwa ma CMC
Faustino et al. Adanenanso mapangidwe amisala osakanikirana pamankhwala anyezi anionic gemini okonda kutengera cystine. A Gemini a gemini okonda amafanizidwanso ndi malo ogwirizana a monomeric ogwiritsa ntchito (C). Mfundo za CMC ya mitud-baticticturetures zidziwike kuti ndizotsika kuposa zomwe zimapangitsa maofesi oyera. Gemini varfacts ndi 1,2-diheptiyoyl-sn-glyceryl-3-phossocholine, solfholipid, phospholipid yamadzi, inali ndi cmc muyezo wa millimor.
Shrethaki ndi Aramaki adafufuza mapangidwe a ma viscoelastic chofunda cham'madzi chosakanikirana a Antionic acid-counionic surticlents pakalibe mchere. Mu kafukufukuyu, N-Dodecyl Glutamate adapezeka kuti ali ndi kutentha kwambiri kwa krafft; Komabe, atalowerera ndi acita acid l-lysine, zimabweretsa micherles ndipo yankho lake adayamba kuchita ngati madzi a Newtonian pa 25 ° C.
6.2 Madzi Abwino Madzi
Madzi abwino osungunuka a AAA a AAS amachitika chifukwa cha kukhalapo kwa zolumikizana zina za co-nh. Izi zimapangitsa AAS kukhala ochulukirapo komanso ochezeka kwambiri kuposa omwe amagwirizana ndi omwe amagwirizana. Kusungunuka kwamadzi kwa n-acyl-l-glotamic acid kumakhala bwino chifukwa cha magulu awiri a carboxyl. Madzi osungunuka a CN (CA) 2 alinso bwino chifukwa pali magulu awiri a ionic a Abracker mu 1 Moleky
6.3 Kutentha kwa Krafft ndi Krafft Point
Kutentha kwa Krafft kumamveka ngati chikhalidwe chosasinthika cha zinthu zosungira anthu omwe kusinthika kumawonjezeka kwambiri pamwambapa. Ionic okonda kukhala ndi chizolowezi chopanga ma hydrate olimba, omwe amatha kupanga madzi. Pa kutentha kwina (otchedwa Krafft Kutentha), kuwonjezeka kwakukulu komanso kosatha kwa solubility ya orfactont nthawi zambiri imawonedwa. Malo a Krafft a Ionic Surtictictor ndi kutentha kwake kwa kmiff ku cmc.
Kusungunuka kumeneku kumawonedwa kwa ionic surfactonts ndipo kumatha kufotokozedwa motere: kusungunuka kwa kutentha kwaulere kwa Krafft Kumaliza Kuonetsetsa kusasinthika kwathunthu, ndikofunikira kukonza mapangidwe azofunikira pa kutentha pamwamba pa malo a Krafft.
Kutentha kwa AAFFFT kwa AAS zaphunziridwa ndi kuphatikizidwa ndi romicfictonti yachilendo.Sshtha ndi Aramaki adapeza kuti micherle ya a Arginine yomwe ili pamwamba pa 2-5 × 10 N-hexadecanoyl aas ndikukambirana ubale womwe ulipo pakati pa kutentha kwawo kwa Krafft ndi Amino Adidi Yotsalira.
Poyesa, zidapezeka kuti kutentha kwa krafft kwa n-hexadecanoyl aas onjezerani kukula kwa amino ad okhazikika (kupatula kutentha kwa ma amino ad okhazikika (kupatula kutsika kwa glycine ndi phenylalanine). Amatha kuti m'magulu onse a Alanine ndi Phenylalanine, kulumikizana kumakhala kolimba kuposa kulumikizana kwa LL mu mawonekedwe olimba a N-hexadecanoyl aas mchere.
Brita et al. adatsimikiza kutentha kwa Krafft kwa New New New New Acino-Certifortoacent Kukhalapo kwa zomangira za Cis-ziwiri ndi kusalabadira komwe kulipo kwa nthawi yayitali kumapangitsa kuchepa kwakukulu mu kutentha kwa Krafft. N-Dodecyl Glutamate adanenedwa kuti ali ndi kutentha kwambiri krafft. Komabe, mosagwirizana ndi amino acid l-lysine adapangitsa kuti ma micleles apangidwe a Micleles omwe ali ngati akumwa anthu a Newtonian pa 25 ° C.
6.4
Mavuto apamwamba a orfacfant amakhudzana ndi kutalika kwa unyolo wa hydrophobic gawo. Zhang et al. Cholinga cha kusokonezeka kwa sodium cocoyl cocoyl glycmy plate (25 ± 0,2) ° 0,5) Yoshimura et al. Cholinganiza pamtundu wa 2c n ma cys mtundu amino acid pamtunda wa 2c n a Cys-zochokera kumayendedwe othandizira. Zinapezeka kuti kusokonezeka kwa masentimita Kutsika ndi kutalika kwa utoto (mpaka n = 8), pomwe chizolowezi chidasinthidwa kuti zigawozi zikuluzikulu ndi n = unyolo wautali wautali.
Zotsatira za CAC1 2 Pamaso pa Mani a Dicarboxtlated Amini acid-zochokera pazomwe zaphunzitsidwanso. Mu maphunzirowa, CAC1 2 idawonjezeredwa pamankhwala atatu a dino acid-mtundu osungira osungira (C12 Malna 2, ndi C12 Gusna 2). Mfundo za Plateau pambuyo CMC idafanizidwa ndipo zidapezeka kuti zovuta zomwe zimatsika kwambiri zimatsika kwambiri kwa ma cac1 2. Izi zimachitika chifukwa cha ntchito ya calcium masikono pa makonzedwe a zowonjezera pamtunda wamafuta. Mavuto a mchere wa N-dodecylaminalomalonalonate ndi N-Dodecylarluateate, mbali inayo, nthawi zambiri amakhalanso pafupifupi 10 mmol-l -1 CAC1 2 Yosema. Pamwamba pa 10 mmol-l -1, kusokonezeka kwa nkhope kumawonjezeka kwambiri, chifukwa cha kupangidwa kwa mpweya wa calcium wa olerera. Kwa mchere wa diadium wa n-dodecyl glutamate, kuwonjezera pang'ono za CAC1 2 kunapangitsa kuchepa kwakukulu pamavuto a CAC1 2 osasinthanso.
Kuti mudziwe ma adsororption a gemini-mtundu AAS pa mawonekedwe a madzi a gasi, mawonekedwe amphamvu kwambiri adatsimikizika pogwiritsa ntchito njira yayikulu yokhotakhota. Zotsatira zake zinawonetsa kuti kwa nthawi yayitali, ma 2c 12 cys a Halnamic oopsa sanasinthe. Kutsika kwa kusokonezeka kwamphamvu kwambiri kumadalira kokha pazinthu, kutalika kwa michira ya hydrophobic, ndi chiwerengero cha michira ya hydrophobic. Kuchulukitsa kukhazikika kwa zochulukitsa, kuchepetsedwa kutalika kwake komanso chiwerengero cha maunyolo chidapangitsa kuti aziwonongeka mwachangu. Zotsatira zomwe zimapezeka kuti zikhale zochulukirapo za C n cys (n = 8 mpaka 12) zidapezeka kuti zili pafupi ndi γ cmlmmy njira yoyesedwa ndi Wilhelmy njira ya Wilhelmy.
Pakuphunzira kwina, ma miseche a sodium dilauryl cystine ma cystine cystine Zomwe zimapangitsa kuti zigwirizane ndi zogwirizana zidasanthulidwanso ndi njira zina. Kuphatikiza kwa Mercaptoenol mpaka 0.1 MM -1sdlc Solution idapangitsa kuti kuwonjezeka mwachangu kuchokera ku 34 Mn-M -1 Mn-M -1. Popeza naclo amatha maxizize zomangira za SDLC ku magulu a acid, osawonedwa pomwe naclo (5 mmol-l -1 Kutumiza ma microsicy ma microscopy ndi magetsi owunikira mwamphamvu adawonetsa kuti palibe ophatikizana adapangidwa mu yankho. Mavuto a SDlc adapezeka kuti akuwonjezeka kuchokera ku 34 mn-m -1 mpaka 60 mn-m -1 kwa mphindi 20.
6.5 Kuyanjana Kwambiri
Mu sayansi ya moyo, magulu angapo aphunzira kugwedezeka kwa mitundu yosiyanasiyana ya aas (diacylglycycident Aas (diacylglycide ogwiritsa ntchito) ndi phospholcified a Arinikisi) ndi phospholpids a Aasginine) ndi ma phospholpids pa mawonekedwe a madzi, pamapeto pake malo osakhala bwino amachititsa kufalitsidwa kwa magetsi.
6.6 Kuphatikizika
Kubalalitsa kwamphamvu kumagwiritsidwa ntchito kudziwa kuphatikizika kwa ma amino acid-colomers ndi gemini okonda kupezeka pamwamba pa cmc, hurr h). Achifwamba omwe amapangidwa ndi C n Chy ndi 2cn Cys ndi yayikulu ndipo amakhala ndi gawo logawa kwambiri poyerekeza ndi ena owonjezera owonjezera. Onse owonjezera kupatula 2c 12 cys nthawi zambiri amapanga pafupifupi 10 nm. Michenje kukula kwa gemini majerekarandu ndi yayikulu kuposa momwe amathandizira anzawo. Kuchulukitsa kwa kutalika kwa hydrocarbon kumapangitsanso kuwonjezeka kwa michenje. Ohta et al. Tafotokozerani zophatikizika za zigawo zitatu zosiyanasiyana za N-dodecyl-phenyl-alanyl-phenyl-phenyl Iwahashi et al. Kusanthula kwa DICRORAL, NMR ndi Vapor Station mapangidwe a n-dodecanoyll-l-glutamic acid, acetonitrile, 1,4-dioxane ndi 1,2-dichlororoene) yokhala ndi zofota za chofowoka zidasanthulidwa ndi ma cichrosism ozungulira, NMR ndi Vapor station stations.
6.7 interfacial adsorption
The interfacial adsorpption ya amino acid - zopangira oyendetsa acid ndi kuyerekezera kwake ndi mnzake wapadera wa mderali ndi imodzi mwazofufuzira. Mwachitsanzo, ma adsorpraction a adsororps a dodecyl etters a fungo lamino acid omwe adalandira kuchokera ku Lep adasanthulidwa. Zotsatira zake zidawonetsa kuti lep onetsetsani madera ocheperako otsika pakati pa gasi.
Bordes et al. Anafufuza njira yothetsera vutoli ndi Adsorption pa mawonekedwe a mafuta atatu a dino acid suni, ndi aminomalonate (ndi 3, 2, ndi 1bon). Malinga ndi lipotili, CMC ya DMCARDY WODZIVETUntunts inali yayikulupo kuposa momwe za monocarboxtract ya monocarch. Izi zimadziwika kuti mapangidwe a maofesi a hydrogen pakati pa ma dicarboxtch opha ndi mamolekyulu oyandikana nawo.
6.8 Gawo
Isotropic distureous magawo amawonedwa kuti azigwiritsa ntchito zochulukirapo m'malo okhazikika kwambiri. Ma mamolekyu ochulukitsa ndi magulu akulu apamwamba kwambiri amakonda kupanga zing'onozing'ono za kupindika pang'ono. Marques et al. anaphunzira gawo la 12s12 / 12SSr ndi 8ls8 / 16Sr Gawo la gawo). Tiyenera kudziwa kuti kwa dera la vesiclic ya The Hisy12 / 12Srser, ma vesicles nthawi zonse amakhala ndi michere, pomwe dera la vesicle la 8s8 / 16ser dongosolo limangokhala ndi ma vesi ma vesicles okha.
Zosakaniza zosokoneza bongo za lysine- ndi seriji: symmetric 12s12 / 12 osewerera (kumanzere) ndi asymmetric 8s8 / 16
6.9 emulsivery luso
Kouchi et al. Kupenda luso la emulsive, kusokonezeka kwa ziwopsezo, kukhazikika, ndi mafayilo a N- [-3-dodecyl-2-Hydroxypropyl] Poyerekeza ndi zopangira zopangira (zopangira zawo zachilendo komanso zamtundu), zotsatira zake zidawonetsa kuti aas amphamvu kwambiri kuposa luso loyendetsa zinthu wamba.
Baczko et al. Makina a synthesired anionic amino acid surfactont ndikufufuza mosiyanasiyana kuti chiwongoledwe cha chirasposcopy chimatha. Mitundu ingapo yophika ya Sulfonate-yophatikizira L-Ala zotumphukira ndi minofu yosiyanasiyana ya hydrophobic (pentyl ~ tetradecyl) idapangidwa ndi Amino Acid ndi O-Sulmobenzoic Anhydride. Wu et al. ma sntutherist sodium mchere wa n-mafuta a acyl aas ndiKufufuza kuthekera kwawo kwa emulsimes mu madzi m'madzi, ndipo zotsatira zake zidawonetsa kuti izi zimachitika bwino ndi ethyl acetate monga gawo lamafuta kuposa ndi n-hexane ngati gawo la mafuta.
6.10 Kupita patsogolo mu kaphatikizidwe ndi kupanga
Kukaniza kwamadzi kolimba kumamveka ngati kuthekera kwa okonda kuthana ndi kupezeka kwa mascamu okhala ndi magnesium ndi magnesium m'madzi olimba, mwachitsanzo, kuthekera kopewa kuthamanga mu sopo wa calcium. Ogwiritsa ntchito okhala ndi zovuta kwambiri madzi ndi othandiza kwambiri pazinthu zotchinga komanso zinthu zosamalira anthu. Kukaniza kwamadzi kolimba kumatha kuwunikiridwa ndikuwerengera kusintha kwa solubility ndi ntchito zapamwamba za okondana kwambiri pamaso pa calcium ion.
Njira ina yowunikira kukana kwa madzi ndikuwerengetsa kuchuluka kapena magalamu a ortictictor sopor sopor sodium oleate wobalalika madzi. M'madera okhala ndi madzi okwera kwambiri, okhazikika kwambiri a calcium ndi magnesium aon ndi michere amatha kupanga zothandiza zina. Nthawi zambiri ion ion imagwiritsidwa ntchito ngati yotsutsa ion yopanga Anionic kanjeza. Popeza calcium calcium ion yomwe imalumikizidwa ndi mamolekyulu ochulukitsa, zimapangitsa kuti ogwiritsa ntchito athetse mosavuta kuti athe kusintha kuti athetsetsetse kuti zinthu zisawonongeke.
Kuphunzira kwa ma hard hard kukana kwa a acid ndi hard acid kutsutsana ndi gulu lowonjezera la carboxyl, ndipo ma acid ndi hard acid amawonjezeka ndi kutalika kwa magulu awiri a Carboxyl. Dongosolo la acid ndi hard kukanacation inali c 12 glyctate <carrtate <c 12 glutamate. Kuyerekeza mthenga wa Diicarboxt-anide ndi dikarboxy-amino orticulant, motero, zimapezeka kuti masholo omaliza anali okwera ndipo ntchito yake imachulukanso ndi acid. Dicarboxtlated N-Alkyl Amanid Acids idawonetsa kuchepetsedwa pamaso pa calcium ions, ndi C Aspartate adapanga zoyera zoyera. C 12 Glutateate adawonetsa ntchito yayitali kwambiri pa 2+ yamphamvu ndipo ikuyembekezeka kugwiritsidwa ntchito kutaya madzi am'madzi.
6.11 Kubalalitsa
Kubalalitsa kumatanthawuza kuthekera kwa zowonjezera zopewera kupewa coalescence ndi kukhazikika kwa zowonjezera pactuctictic.Kubalalika ndi chinthu chofunikira kwambiri chazokonda zomwe zimawapangitsa kuti azigwiritsa ntchito zotupa, zodzoladzola komanso mankhwala osokoneza bongo.Wogwiritsa ntchito wobalalika ayenera kukhala ndi eyiti, ether kapena amino kulumikizana pakati pa gulu la hydrophobic ndi gulu la hydrophilic.
Nthawi zambiri, anionic okonda monga alkanolamido sulfid ndi mindaholiyolforents monga othandizira kufalitsa ma sopo wa calcium.
Kuyesayesa kwambiri kafukufuku watsimikiza kubvunta la AAS, pomwe N-Lauroyl lysine adapezeka kuti akugwirizana ndi madzi komanso ovuta kugwiritsa ntchito zodzikongoletsera.Munkhani ino, N-Acyl-Suctitoted Amani Acids ali ndi mwayi wapamwamba ndipo amagwiritsidwa ntchito popanga zodzikongoletsera kuti zikhale bwino.
07 Kuthana
Zojambula zapadera, makamaka zomata zomangamanga, zimakhala zowopsa kwambiri kwa zolengedwa zam'madzi. Matenda awo pachimake amachitika chifukwa cha chodabwitsa cha adsordeppppppppta-roones-ronation of orfactotions pa mawonekedwe am'manja. Kuchepetsa cmc ya okonda nthawi zambiri kumabweretsa nyonga yazitsulo kwa okonda kuchuluka, komwe nthawi zambiri kumabweretsa vuto lawo loopsa. Kuchuluka kwa kutalika kwa hydrophobic unyoli wa okonda zimabweretsanso kuwonjezeka kwa zinthu zoopsa.AAa a aasi ambiri amakhala otsika kapena osalondera kwa anthu ndi chilengedwe (makamaka am'mimba) ndipo ndioyenera kugwiritsa ntchito chakudya, mankhwala opanga mankhwala ndi zodzoladzola.Ofufuza ambiri asonyeza kuti amino acid solifants ndi odekha komanso osakwiyitsa khungu. Ogwiritsa ntchito a Arlinine-kutengera amadziwika kuti sakhala owopsa kuposa anzawo omwe ali mdera.
Brita et al. anaphunzira zojambulajambula ndi zoopsa za amino acines acids ndi zochokera ku tyrosine (tyr), hydroxypline (lysroxypline yokhazikika kwa daphnia (IC 50). Adapanga ma c6cs a dodecyltrimethylammomonium bromidesmomonium (dtab) / ma bnaly-zotumphukira komanso kapena kuwonetsa kuti zosakaniza zawo zonse zidali zoopsa kuposa mattictive.
Rosa et al. kufufuzana (mayanjano) a DNA ku Aminic acid acictions. Mosiyana ndi zojambula zamtengo wapatali zachikhalidwe, zomwe nthawi zambiri zimawoneka ngati zoopsa, kulumikizana kwa chiphunzitso amino acid surtictonts akuwoneka kuti siwopatsirana. AAS a CAAR imakhazikitsidwa pa arlinine, yomwe imakhazikika mokhazikika ndi zopindika zomwe zimaphatikizidwa ndi anyezi oyendetsa anyezi. Amino Adid-adani acid inhibitors amatchulidwanso kuti siwopatsirana. Izi zimapangidwa mosavuta ndi chiyero chachikulu (mpaka 99%), mtengo wotsika, mosavuta biodegrad chilengedwe, ndikusungunuka kwathunthu pazama TV. Kafukufuku angapo asonyeza kuti sulfure-okhala ndi amino acid surfactonts ndi apamwamba poletsa zoletsa.
Pakafukufuku waposachedwa, perinelli et al. adanenanso za mbiri yoyeserera ya rhamothuliplas poyerekeza ndi oyendetsa okondana. Rhamonsiils amadziwika kuti amachita ngati zowonjezera. Adanenanso za rhamonsipids pa epithelial information mankhwala a macrorolecular.
08 antimicrobial ntchito
Zochita za antimicrobial za orfactonts zitha kuwunikiridwa ndi zoletsa zochepa. Zochita za Antimicrobial za arginine-zochokera kuzinthu zaphunziridwa mwatsatanetsatane. Mabakiteriya olakwika adapezeka kuti ali okhudzana ndi a Arlinine-zozizwitsa kuposa mabakiteriya omwe ali ndi gramu. Zochita za Antimicrobial za orfactonts nthawi zambiri zimawonjezereka ndi kupezeka kwa hydroxyl, cyclopropane kapena zomangira zosavomerezeka mkati mwa ma unyolo. Camillo et al. Zinawonetsa kuti kutalika kwa ma acyl maunyolo amatsimikizira mtengo wa HLB (Hydrophilic-Lipophilic Stoval) ya molekyulu, ndipo izi zimapangitsa kuti azitha kusokoneza membene. N α-acylarigine mester ndi gulu lina lofunikira lazovala zotupa ndi ziwonetsero zowoneka bwino ndipo ndizochepa kapena zosaneneka kapena zopanda vuto. Kafukufuku wa pa Kulumikizana kwa NCY-Acylarigine methyl ESTS ESRY-PHOSPHERDRICOXYL NDI 3-PHETESLESTRICOLIINE, ndi zomwe sizikhala ndi zotchinga zakunja. adawonetsa kuti gulu la dati la okonda lili ndi zotsutsana ndi zotsatira zoyipa zomwe zidawonetsa kuti zopangirazi zimakhala ndi ntchito yabwino ya antibacterial.
09 rheological
Mitundu yazachilengedwe ya okonda amatenga gawo lofunikira kwambiri posankha ndikulosera za mafakitale osiyanasiyana, kuphatikizapo chakudya m'magulu osiyanasiyana, mankhwala othandizira, mankhwala osokoneza bongo komanso zinthu zapakhomo. Maphunziro ambiri apangidwa kuti akambirane ubale womwe ulipo pakati pa ma viscoelastity amino acid surfactont ndi cmc.
Mapulogalamu 10 opanga zodzikongoletsera
AA amagwiritsidwa ntchito popanga zinthu zambiri zantchito.Potaziyamu n-cocoyl glycte imapezeka kuti imakhala yodekha pakhungu ndipo imagwiritsidwa ntchito poyeretsa nkhope kuti ichotse sludge ndi zodzoladzola. N-Acyl-L-Glutamic acid ali ndi magulu awiri a Carboxyl, omwe amapangitsa kuti isungunuke madzi ambiri. Mwa aas awa, aad potengera acids acids amagwiritsidwa ntchito kwambiri poyeretsa nkhope kuti achotse sludge ndi zodzoladzola. Aa ndi unyolo wa c 18 umagwiritsidwa ntchito ngati ma emulsifiers pazinthu zosamalira khungu, ndipo N-Lauryl Alanine Mchere amadziwika kuti amapanga khungu ndipo motero lizitha kugwiritsidwa ntchito pakupanga kwa ana. AAS ogwiritsa ntchito N-Lauryl-ogwiritsa ntchito mankhwala opangira mano ali ndi vuto lofanana ndi sopo ndi enzyme - cholepheretsa.
Kwa zaka makumi angapo zapitazi, kusankha kwa okonda kupanga zodzola, zinthu zomwe zimasamalira payekha komanso mankhwala osokoneza bongo omwe amayang'ana kwambiri pozindikira zochepa, kufatsa, kudekha pakukhudza komanso chitetezo. Ogwiritsa ntchito izi amazindikira bwino za kukwiya, zoopsa ndi zachilengedwe.
Masiku ano, aas amagwiritsidwa ntchito popanga ma shampoos ambiri, sopo wa tsitsi chifukwa cha zabwino zawo pazachikhalidwe zawo zachikhalidwe muzodzikongoletsera ndi zosamalira payekha.Ma procanited-kutengera zopangidwa ndi mapuloteni ali ndi zofunikira pazinthu zamwini. AAS ena amakhala ndi luso lopanga mavidiyo, pomwe ena ali ndi luso lokhomera bwino.
Amino acid ndiofunika mwachilengedwe kuwononga zinthu zomwe zimayambitsa chivundikiro cha Stratum. Ma cell a Epidel atamwalira, amakhala gawo la mitengo ya stratum ndi ma Nangentillar pang'onopang'ono amawonongeka kwa amino acid. Amino acid a Amani acid nthawi yomweyo amanyamulidwanso ndi mitengo ya stratum, komwe amatenga zinthu zonenepa kapena zonenepa mu zipatso za epirthem, potero ndikuwongolera zotupa za pakhungu. Pafupifupi 50% ya chinthu chachilengedwe chomwe chimapangidwa khungu limapangidwa ndi amino acid ndi kuwonongeka kwa zino.
Collagen, zodzikongoletsera wamba, zilinso ndi amino acid omwe amasuntha khungu.Mavuto a pakhungu monga kufooka ndi kuwuluka kumachitika chifukwa chosowa ma amino acid. Kafukufuku wina adawonetsa kuti kusakaniza amino acid ndi mafuta ochepetsera khungu, ndipo madera omwe akhudzidwawo adabwezedwanso.
Amacino acid apezekanso kuti ndizothandiza kwambiri posamalira.Tsitsi lowuma, losasunthika lingatanthauze kuchepa kwa ma amino acid omwe amawonongeka kwambiri. Amacino acid ali ndi kuthekera kolowa mu stecle mu shaft ya tsitsi ndikutenga chinyezi pakhungu.Kutha kwa amino acid mokhazikika pamasamba kumawapangitsa kukhala othandiza kwambiri mu shampoos, utoto wa tsitsi, zowonda tsitsi, komanso kukhalapo kwa amino acid kukhala olimba.
Zinthu 11 zodzikongoletsera za tsiku ndi tsiku
Pakadali pano, pali kufunikira kokulira kwa matenda opatsirana pochokera padziko lonse lapansi.Aa amadziwika kuti ali ndi luso loyeretsa bwino, kuthekera kofananira ndi katundu wofewetsa, zomwe zimawapangitsa kukhala oyenera kwa malo otsekemera, shampoos, amasungunuka thupi ndi mapulogalamu ena.Aspartic ashoteric a AAHOTERIC AAS imanenedwa kuti ikhale yotsekemera kwambiri yokhala ndi zotumphukira. Kugwiritsa ntchito zosakaniza zotchinga zopangidwa ndi n-alkyl-β-β-β-β-β-β-β-β-β-β Kupanga kwamadzi kopangidwa ndi N-Cocoyl-β-Aminopropheionate yaimbidwa kuti ikhale yotsekemera ya madontho opanga mafuta pachitsulo. Aminocarboxyycyylic acid Surticturent, Chch 2 NHCHE 2 NHCOOPRICS acid yodziwika bwino ndipo imaperekanso bata.
Kukonzekera kwa mawonekedwe opindika potengera N-(N-N'-N-Acyl-β-β-β-β-β-β-alalanine adanenedwa ndi a Kenune adanenedwa ndi luso lawo lotsuka ndi kuphwanya kwa chisotidwe ndi kuthyolako kofewa. Kao adapanga zotchinga zotchinga zochokera ku N-Acyl-1 -N-hydroxy-β-anine ndikunena kuti kukwiya kwa khungu, kukana madzi ndi madzi okwera kwambiri ndi mphamvu zokwera.
Kampani yaku Japan Ajinomoto imagwiritsa ntchito mabwalo otsika kwambiri komanso mosavuta chifukwa cha L-Glutamic acid, l-arminic ndi l-lysine monga zosakaniza zazikulu mu shampoos, zodzikongoletsera ndi zodzola (Chithunzi 13). Kutha kwa enzyme zowonjezera pamitundu yotsekemera kuti muchotse zosoweka za mapuloteni zanenedwanso. N-Acyl Aas ochokera ku Glutamic acid, Alanine, methylglycine, sefir ndi aspartic acid adanenedwa kuti awagwiritsire ntchito njira zabwino zamadzi. Izi sizowonjezera mamasukidwe, ngakhale kutentha kochepa kwambiri, ndipo kumatha kusamutsidwa mosavuta kuchokera ku chotengera chosungira cha chipangizocho kuti mulandire zikopa zoluma.
Post Nthawi: Jun-09-2022